immagine MTHFR mutation: research and diagnosis.

13/05/22 - Deavocado

MTHFR mutation: research and diagnosis.

MTHFR mutation

The term mutation indicates specifically a genetic defect, hence in the DNA. A study conducted by the Human Genome Project has demonstrated that the faulty transcription of the DNA implies the bad functioning of a gene present in the body and that it carries out an important role.

What happens to the body?

The mutation of this gene causes a loss in the production of Methylfolate with a variation that hovers between 30% and 70% compared to the normal dose. The body goes into deficit causing a range of serious problems of which it is not always easy to find the main source, such as:

  • Cardiac illnesses
  • Predisposition to cancer
  • Hair loss
  • Difficulty of liver to detox
  • Depression and anxiety
  • Interruption of pregnancy


Homocysteine is a substance present in our body which could cause different illnesses and dysfunctions, such as abortion, osteoporosis, and cancer, if it does not undergo the necessary process with methylation. To manage hyperhomocysteinemia caused by a Genetic Deficit of the Enzyme Methylenetetrahydrofolate reductase (MTHFR) integration with Methylfolate is essential. During conception, it is always advisable to carry out a test to check MTHFR mutation. If the diagnosis is positive, it would mean that you are unable to metabolise the folate correctly. The consequence of this diagnosis would be to create a malformation of the neural tube, which is precisely the structure that gives rise to all the baby’s nervous system.

Cosa fare?

Methylfolate is the metabolically active form of Folate Acid and one of its functions is to reconvert homocysteine into methionine, including in the presence of genetic mutation. It is advisable to take vitamins B6, B12, B2 and Zinc because they are enzymatic co-factors which strengthen the function of Methylfolate.

Deavocado Conceive is the supplement which has changed its structure to be increasingly close to the needs of women, of mothers. Methylfolate has been introduced, a precious aid for women who are trying to conceive and to meet a range of problems connected with the MTHFR mutation. At European level, the MTHFR mutation manifests itself in 3.5% of the total population, the healthy carriers are 43_45%, while those who manifest the illness are 8-15% of the cases.

The symptoms

Knowing your body is essential to keep yourself healthy. Regular check-ups are required to monitor your actual state of health.

In any case, some symptoms are sure signs that something isn’t right. These are the symptoms which could highlight the mutation in your body:

  • Higher than normal levels of homocysteine.
  • Intolerances and allergies.
  • Diabetes.
  • Asthma.
  • Thyroid alterations.
  • Less ability to detox the liver, especially from heavy metals.
  • Dependence on alcohol, drugs, gambling, etc.
  • Predisposition to the formation of cancer.
  • “Psycho-somatic” illnesses, both small and big.
  • Absence or almost of folate: the most common symptoms include fatigue, sense of dizziness and even forgetfulness.
  • Gastrointestinal difficulties: an example could be IBS, Celiac disease or Chron’s disease.
  • Self-immune illnessss: for example, fibromyalgia.
  • Alzheimer’s disease.
  • Lengthy periods of depression and anxiety.

If you have one or more of these symptoms, we advise you to contact your medical physician, and always take care of yourself.
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